Bishun N P, Valera N, Williams D C
Cytobios. 1978;23(91-92):177-85.
Experiments were carried out to determine the cytogenetic effects of the antibiotic bleomycin (BLM) in rats using the bone marrow system. A total of eighteen male and eighteen female Sprague-Dawley rats were injected with varying concentration of BLM, over varying periods of time. The results revealed that at low concentrations BLM showed no alteration in the ploidy or the morphology of rat chromosomes. This however, was not the case when the dose or administration period was increased.
利用骨髓系统进行实验以确定抗生素博来霉素（BLM）对大鼠的细胞遗传学效应。总共18只雄性和18只雌性斯普拉格-道利大鼠在不同时间段内被注射了不同浓度的BLM。结果显示，低浓度时BLM对大鼠染色体的倍性或形态没有影响。然而，当剂量或给药时间增加时，情况并非如此。
