Bleomycin-induced structural chromosomal aberrations in spermatogonia and bone-marrow cells of mice.
作者信息
van Buul P P, Goudzwaard J H
出版信息
Mutat Res. 1980 Feb;69(2):319-24. doi: 10.1016/0027-5107(80)90096-2.
PMID:6153758
Abstract
The induction of structural chromosomal aberrations by bleomycin (BLM) was studied in bone-marrow cells and spermatogonia of the mouse at doses of 10, 20, 40 and 80 mg/kg. BLM induced genetically important reciprocal translocations in stem-cell spermatogonia as measured with the spermatocyte test, and the response of bone-marrow cells to BLM was not markedly different from that of spermatogonia.
摘要
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