自身免疫性甲状腺疾病儿科患者的抗核抗体阳性

Antinuclear antibody positivity in pediatric patients with autoimmune thyroid disease.

作者信息

Inamo Y, Harada K

机构信息

Department of General Pediatrics, Nerima Hikarigaoka Hospital, Nihon University School of Medicine, Tokyo, Japan.

出版信息

J Rheumatol. 1997 Mar;24(3):576-8.

PMID:9058668

Abstract

OBJECTIVE

The incidence of antinuclear antibody (ANA) positivity was investigated in pediatric patients with autoimmune thyroid diseases.

METHODS

Subjects were 21 untreated patients with Graves' disease, 12 untreated patients with Hashimoto's disease, and 16 untreated patients with non-autoimmune thyroid disease, including one patient with Plummer's disease, 11 patients with simple goiter (probable), and 4 patients with cretinism. Patients with Graves' disease were treated with either propylthiouracil or methimazole. ANA was measured using HEp-2 cells. Anti-dsDNA antibody was measured using double stranded DNA derived from an Escherichia coli plasmid.

RESULTS

The incidence of ANA positivity was significantly higher in patients with untreated Graves' disease (n = 21; age range 9-15 yrs) than in Hashimoto's thyroiditis (n = 12; age range 7-15 yrs) (p < 0.03, Fisher's exact probability test). However, the 2 diseases were not significantly different with respect to anti-dsDNA antibody positivity. Most of the ANA positive patients with Graves' disease required treatment for more than 2 years, unlike the 6 ANA negative patients (p < 0.002, Fisher's exact probability test).

CONCLUSION

We conclude that ANA positivity may predict a poor response to antithyroid drugs in Graves' disease.

摘要

目的

研究自身免疫性甲状腺疾病患儿抗核抗体（ANA）阳性的发生率。

方法

研究对象为21例未经治疗的格雷夫斯病患者、12例未经治疗的桥本氏病患者以及16例未经治疗的非自身免疫性甲状腺疾病患者，其中包括1例毒性结节性甲状腺肿患者、11例单纯性甲状腺肿（疑似）患者和4例呆小病患者。格雷夫斯病患者接受丙硫氧嘧啶或甲巯咪唑治疗。使用HEp-2细胞检测ANA。使用源自大肠杆菌质粒的双链DNA检测抗双链DNA抗体。

结果

未经治疗的格雷夫斯病患者（n = 21；年龄范围9 - 15岁）的ANA阳性发生率显著高于桥本氏甲状腺炎患者（n = 12；年龄范围7 - 15岁）（p < 0.03，Fisher精确概率检验）。然而，这两种疾病在抗双链DNA抗体阳性方面无显著差异。与6例ANA阴性的格雷夫斯病患者不同，大多数ANA阳性的格雷夫斯病患者需要治疗超过2年（p < 0.002，Fisher精确概率检验）。