Gaitini L, Fradis M, Vaida S, Krimerman S, Beny A
Department of Anesthesiology, Bnai-Zion Medical Center, Haifa, Israel.
Anaesthesia. 1997 Feb;52(2):165-8. doi: 10.1111/j.1365-2044.1997.11-az011.x.
Neuroleptic malignant syndrome is a severe and potentially fatal reaction to neuroleptic drugs. Treatment requires withdrawal of the neuroleptic agent, metabolic and cardiovascular support, physical cooling and treatment with dantrolene sodium and bromcriptine mesylate. We report a therapeutic success of plasmapheresis in a case of neuroleptic malignant syndrome in which conventional therapy had failed. We postulate that plasmapheresis may prove to be a useful tool in treating this frequently fatal disease.
神经阻滞剂恶性综合征是对神经阻滞剂药物的一种严重且可能致命的反应。治疗需要停用神经阻滞剂药物，给予代谢和心血管支持，进行物理降温，并使用丹曲林钠和甲磺酸溴隐亭治疗。我们报告了1例常规治疗失败的神经阻滞剂恶性综合征患者经血浆置换治疗成功的病例。我们推测血浆置换可能被证明是治疗这种常致命疾病的一种有用工具。
