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痛风在新西兰的发病率正在上升。

Gout is on the increase in New Zealand.

作者信息

Klemp P, Stansfield S A, Castle B, Robertson M C

机构信息

Queen Elizabeth Hospital, Rotorua, New Zealand.

出版信息

Ann Rheum Dis. 1997 Jan;56(1):22-6. doi: 10.1136/ard.56.1.22.

Abstract

OBJECTIVE

To determine the current prevalence of hyperuricaemia and gout in New Zealand Maori and Europeans for comparison with previous studies.

METHODS

342 Maori and 315 European men and women aged 15 years and older were studied by personal interview and a musculoskeletal system examination. The 1977 ARA criteria for gout in a survey setting were used and serum uric acid was determined by a uricase method. The data were compared with those of previous New Zealand studies.

RESULTS

Gout was significantly more common in Maori (6.4%) than Europeans (2.9%) (delta = 3.6%, 95% confidence interval 0.4 to 6.8) and in Maori men (13.9%) than in European men (5.8%) (delta = 8.1%, 95% CI 1.0 to 15.2). Hyperuricaemia was significantly more common in Maori men (27.1%) than in European men (9.4%) (delta = 17.7%, 95% CI 8.3 to 27.1) and in Maori women (26.6%) than in European women (10.5%) (delta = 16.1%, 95% CI 8.5 to 23.7). At least 14% of hyperuricaemic individuals were receiving diuretics, of whom 78% were women. Comparison with previous studies shows that the prevalence of gout has increased in both Maori and Europeans, particularly in men. In Maori men the prevalence of gout has risen from 4.5-10.4% previously to 13.9%, and in European men from 0.7%-2.0% previously to 5.8%. Clinical differences included a stronger family history, earlier age at onset, and a higher frequency of tophi and polyarticular gout in Maori than Europeans. Of those with gout, 62% of Maori and 63% of Europeans were hyperuricaemic on the day surveyed and six (19.4%) were on diuretics. Treatment of gout was inadequate in most cases.

CONCLUSIONS

Hyperuricaemia and gout remain common among Maori. Of concern is that the prevalence of gout appears to be on the increase, not only in Maori but also in Europeans in New Zealand.

摘要

目的

确定新西兰毛利人和欧洲人中高尿酸血症和痛风的当前患病率,以便与以往研究进行比较。

方法

通过个人访谈和肌肉骨骼系统检查,对342名毛利人和315名年龄在15岁及以上的欧洲男性和女性进行了研究。采用1977年美国风湿病学会(ARA)在调查环境中的痛风诊断标准,并通过尿酸酶法测定血清尿酸。将数据与新西兰以往的研究数据进行比较。

结果

痛风在毛利人(6.4%)中比在欧洲人(2.9%)中更为常见(差值=3.6%,95%置信区间0.4至6.8),在毛利男性(13.9%)中比在欧洲男性(5.8%)中更为常见(差值=8.1%,95%置信区间1.0至15.2)。高尿酸血症在毛利男性(27.1%)中比在欧洲男性(9.4%)中更为常见(差值=17.7%,95%置信区间8.3至27.1),在毛利女性(26.6%)中比在欧洲女性(10.5%)中更为常见(差值=16.1%,95%置信区间8.5至23.7)。至少14%的高尿酸血症患者正在服用利尿剂,其中78%为女性。与以往研究相比,痛风的患病率在毛利人和欧洲人中均有所增加,尤其是在男性中。在毛利男性中,痛风的患病率从之前的4.5%-10.4%上升到了13.9%,在欧洲男性中,从之前的0.7%-2.0%上升到了5.8%。临床差异包括毛利人的家族病史更强、发病年龄更早,以及痛风石和多关节痛风的发生率高于欧洲人。在接受调查的当天,患有痛风的人中,62%的毛利人和63%的欧洲人血尿酸过高,6人(19.4%)正在服用利尿剂。在大多数情况下,痛风的治疗并不充分。

结论

高尿酸血症和痛风在毛利人中仍然很常见。令人担忧的是,痛风的患病率似乎不仅在毛利人中,而且在新西兰的欧洲人中都在上升。

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本文引用的文献

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Gout in the Maori.毛利人中的痛风
Ann Rheum Dis. 1960 Jun;19(2):120-5. doi: 10.1136/ard.19.2.120.
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Direct determination of uric acid using uricase.使用尿酸酶直接测定尿酸。
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