Bailey A R, Burchett K R
Queen Elizabeth Hospital, Norfolk.
Br J Anaesth. 1997 Jan;78(1):97-9. doi: 10.1093/bja/78.1.97.
Dopamine is a naturally occurring catecholamine with actions in the central nervous system and endocrine systems, including inhibition of prolactin release from the pituitary gland. Prolactin secretion has been shown to be increased in response to physiological stress, while hypoprolactinaemia is associated with a reduction in the cellular immune response. We have investigated the effects of low-dose infusion of dopamine 2.5 micrograms kg-1 min-1 on serum concentrations of prolactin in critically ill patients. Six hours after commencing the dopamine infusion, mean serum prolactin concentration had decreased from 746.95 to 128.9 mu. litre-1 (normal range 84-488 mu. litre-1). This represented a mean reduction of 79.2%, with 35% of patients exhibiting a subnormal concentration while receiving dopamine. This reduction was reversed after cessation of dopamine and reproducible on re-institution. This suppression of the release of dopamine may be a detrimental side effect of low-dose dopamine infusion in critically ill patients.
多巴胺是一种天然存在的儿茶酚胺，作用于中枢神经系统和内分泌系统，包括抑制垂体前叶催乳素的释放。已表明催乳素分泌会因生理应激而增加，而低催乳素血症与细胞免疫反应降低有关。我们研究了以2.5微克/千克·分钟的低剂量输注多巴胺对重症患者血清催乳素浓度的影响。开始输注多巴胺6小时后，血清催乳素平均浓度从746.95降至128.9微升/升（正常范围84 - 488微升/升）。这意味着平均降低了79.2%，35%的患者在接受多巴胺治疗时催乳素浓度低于正常水平。多巴胺停用后这种降低情况逆转，重新使用时可再现。多巴胺释放的这种抑制可能是低剂量多巴胺输注对重症患者的一种有害副作用。
