William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, UK.
Br J Pharmacol. 2012 Apr;165(7):2015-33. doi: 10.1111/j.1476-5381.2011.01588.x.
Inotropes and vasopressors are biologically and clinically important compounds that originate from different pharmacological groups and act at some of the most fundamental receptor and signal transduction systems in the body. More than 20 such agents are in common clinical use, yet few reviews of their pharmacology exist outside of physiology and pharmacology textbooks. Despite widespread use in critically ill patients, understanding of the clinical effects of these drugs in pathological states is poor. The purpose of this article is to describe the pharmacology and clinical applications of inotropic and vasopressor agents in critically ill patients.
正性肌力药和血管加压药是具有生物学和临床重要性的化合物，它们来源于不同的药理学类别，作用于体内一些最基本的受体和信号转导系统。有 20 多种此类药物在临床上常用，但除了生理学和药理学教科书中有少量相关药理学综述外，很少有关于这些药物的综述。尽管这些药物在危重病患者中广泛使用，但对这些药物在病理状态下的临床效果的认识却很差。本文旨在描述正性肌力药和血管加压药在危重病患者中的药理学和临床应用。
