Galletly D C, Larsen P D
Wellington School of Medicine, New Zealand.
Br J Anaesth. 1997 Jan;78(1):100-1. doi: 10.1093/bja/78.1.100.
We have examined in eight male volunteers the effect of midazolam sedation on the relationship between timing of spontaneous ventilations and heart beat. On 2 study days, subjects received either midazolam 0.1 mg kg-1 or saline placebo while recordings were made of ECG and ventilatory impedance pneumography. We observed in all midazolam-treated subjects clear evidence of synchronous or non-synchronous coupling between ventilation and heart beat. Non-synchronous coupling was seen in two placebo-treated subjects, one of whom had slept during the recording period. We conclude that cardioventilatory coupling is a major determinant of ventilatory timing in sedated subjects.
我们在8名男性志愿者身上研究了咪达唑仑镇静对自主呼吸时间与心跳之间关系的影响。在两个研究日，受试者分别接受0.1mg/kg的咪达唑仑或生理盐水安慰剂，同时记录心电图和通气阻抗肺量图。我们在所有接受咪达唑仑治疗的受试者中观察到呼吸与心跳之间同步或不同步耦合的明确证据。在两名接受安慰剂治疗的受试者中观察到不同步耦合，其中一名在记录期间睡着了。我们得出结论，心肺耦合是镇静受试者呼吸时间的主要决定因素。
