Miles K A, Kelley B B
Centre for Functional Imaging, Wesley Research Institute, Auchenflower, Brisbane, Queensland, Australia.
Br J Radiol. 1997 Jan;70:74-9. doi: 10.1259/bjr.70.829.9059299.
Analysis of time-attenuation data has enabled CT to measure capillary permeability within the brain and kidney. As yet, such techniques have not been applied to nodal masses in patients with lymphoma. Tumour angiogenesis is known to produce capillaries that exhibit increased permeability and CT measurements of permeability could therefore potentially provide a marker of tumour viability. This study aims to determine the feasibility and limitations of CT measurement of capillary permeability within lymphoma nodal masses. Six patients with biopsy proven lymphoma have been studied. Time-attenuation curves from the aorta and nodal mass were generated from a single-location dynamic sequence of images acquired over 3 min following an intravenous bolus of iopamidol. A nuclear medicine data processing technique, Patlak analysis, was used to calculate capillary permeability and blood volume within the nodal mass. Renal blood vessel permeability was also determined in four patients. Median lymph node permeability to iopamidol was 88.5 microliters min-1 ml-1 (range 36.4-198.5 microliters min-1 ml-1). The correlation coefficient of the linear fit for the Patlak analysis ranged from 0.74 to 0.95 and was greater than 0.9 for regions of interest of 150 pixels or more (256 x 256 matrix). The values for renal permeability (442 microliters min-1 ml-1; range: 349-589 microliters min-1 ml-1) were comparable to those previously reported. Functional images of permeability were also obtained. The study has confirmed the feasibility of CT measurements of capillary permeability within nodal masses. The technique combines anatomical imaging and functional information within one examination and has potential application in monitoring the response of lymphoma to therapy.
对时间-衰减数据的分析已使CT能够测量脑和肾内的毛细血管通透性。迄今为止，此类技术尚未应用于淋巴瘤患者的淋巴结肿块。已知肿瘤血管生成会产生通透性增加的毛细血管，因此CT测量通透性可能会提供肿瘤存活的标志物。本研究旨在确定CT测量淋巴瘤淋巴结肿块内毛细血管通透性的可行性和局限性。对6例经活检证实为淋巴瘤的患者进行了研究。在静脉推注碘帕醇后3分钟内，从单部位动态图像序列生成主动脉和淋巴结肿块的时间-衰减曲线。采用一种核医学数据处理技术——Patlak分析，来计算淋巴结肿块内的毛细血管通透性和血容量。还对4例患者测定了肾血管通透性。淋巴结对碘帕醇的通透性中位数为88.5微升·分钟⁻¹·毫升⁻¹（范围36.4 - 198.5微升·分钟⁻¹·毫升⁻¹）。Patlak分析线性拟合的相关系数范围为0.74至0.95，对于150像素或更多像素（256×256矩阵）的感兴趣区域，相关系数大于0.9。肾通透性值（442微升·分钟⁻¹·毫升⁻¹；范围：349 - 589微升·分钟⁻¹·毫升⁻¹）与先前报道的值相当。还获得了通透性的功能图像。该研究证实了CT测量淋巴结肿块内毛细血管通透性的可行性。该技术在一次检查中结合了解剖成像和功能信息，在监测淋巴瘤对治疗的反应方面具有潜在应用价值。
