Groves Ashley M, Wishart Gordon C, Shastry Manu, Moyle Penelope, Iddles Sharon, Britton Peter, Gaskarth Mathew, Warren Ruth M, Ell Peter J, Miles Kenneth A
Institute of Nuclear Medicine, UCL, UCH, 235 Euston Rd, London NW1 2BU, UK.
Eur J Nucl Med Mol Imaging. 2009 Mar;36(3):416-21. doi: 10.1007/s00259-008-0948-1. Epub 2008 Sep 26.
To assess the feasibility and first experience of combined (18)F-FDG-PET)/dynamic contrast-enhanced (DCE) CT in evaluating breast cancer.
Nine consecutive female patients (mean age 64.2 years, range 52-74 years) with primary breast carcinoma were prospectively recruited for combined (18)F-FDG PET/DCE-CT. Dynamic CT data were used to calculate a range of parameters of tumour vascularity, and tumour (18)F-FDG uptake (standardized uptake value, SUVmax) was used as a metabolic indicator.
One tumour did not enhance and was excluded. The mean tumour SUVmax was 7.7 (range 2.4-26.1). The mean values for tumour perfusion, perfusion normalized to cardiac output, standard perfusion value (SPV) and permeability were 41 ml/min per 100 g (19-59 ml/min per 100 g), 0.56%/100 g (0.33-1.09%/100 g), 3.6 (2.5-5.9) and 0.15/min (0.09-0.30/min), respectively. Linear regression analysis showed a positive correlation between tumour SUV and tumour perfusion normalized to cardiac output (r=0.55, p=0.045) and a marginal correlation between tumour SUV and tumour SPV (r=0.19, p=0.065). There were no significant correlations between tumour SUV and tumour perfusion (r=0.29, p=0.401) or permeability (r=0.03, p=0.682).
The first data from combined (18)F-FDG-PET/DCE-CT in breast cancer are reported. The technique was successful in eight of nine patients. Breast tumour metabolic and vascular parameters were consistent with previous data from (15)O-H(2)O-PET.
评估联合（18）F - FDG - PET）/动态对比增强（DCE）CT在评估乳腺癌中的可行性及首次应用经验。
前瞻性招募9例连续的原发性乳腺癌女性患者（平均年龄64.2岁，范围52 - 74岁）进行联合（18）F - FDG PET/DCE - CT检查。利用动态CT数据计算一系列肿瘤血管生成参数，并将肿瘤（18）F - FDG摄取（标准化摄取值，SUVmax）用作代谢指标。
1个肿瘤未强化，被排除。肿瘤平均SUVmax为7.7（范围2.4 - 26.1）。肿瘤灌注、心输出量标准化灌注、标准灌注值（SPV）和通透性的平均值分别为每100 g 41 ml/min（19 - 59 ml/min每100 g）、0.56%/100 g（0.33 - 1.09%/100 g）、3.6（2.5 - 5.9）和0.15/min（0.09 - 0.30/min）。线性回归分析显示肿瘤SUV与心输出量标准化肿瘤灌注之间呈正相关（r = 0.55，p = 0.045），肿瘤SUV与肿瘤SPV之间呈边缘相关（r = 0.19，p = 0.065）。肿瘤SUV与肿瘤灌注（r = 0.29，p = 0.401）或通透性（r = 0.03，p = 0.682）之间无显著相关性。
报告了联合（18）F - FDG - PET/DCE - CT用于乳腺癌检查的首批数据。该技术在9例患者中的8例中取得成功。乳腺肿瘤代谢和血管参数与先前（15）O - H₂O - PET的数据一致。
