Dugdale P E, Miles K A, Bunce I, Kelley B B, Leggett D A
Centre for Functional Imaging, Wesley Research Institute, and Department of Radiology, Wesley Hospital, Brisbane, Queensland, Australia.
J Comput Assist Tomogr. 1999 Jul-Aug;23(4):540-7. doi: 10.1097/00004728-199907000-00010.
Structural CT criteria such as nodal size and appearance have a poor correlation with the grade and activity of a lymphoma mass. This study investigates the potential for functional CT perfusion and permeability measurements to assess lymphoma grade and activity.
Thirty-nine patients with proven lymphoma underwent 47 dynamic contrast-enhanced CT studies. Lymphoma grade was classified as low or intermediate/high. In seven patients who underwent repeated studies, measurements were correlated against change in disease activity in the intervening period.
Median perfusion values were higher in active disease (0.55 vs. 0.37 ml/min/ml) and intermediate/high-grade lymphoma (0.56 vs. 0.46 ml/min/ml). Perfusion below 0.2 ml/min/ml implied inactive disease (p < 0.03), whereas > 0.5 ml/min/ml suggested intermediate/high-grade lymphoma (p = 0.11). Median values of permeability were little different between patient groups. Only perfusion fell when disease became inactive.
Only CT perfusion measurements of nodes have potential for assessing lymphoma grade, activity, and treatment response.
诸如淋巴结大小和形态等CT结构标准与淋巴瘤肿块的分级及活性相关性较差。本研究探讨CT灌注和通透性功能测量评估淋巴瘤分级及活性的潜力。
39例确诊淋巴瘤患者接受了47次动态对比增强CT检查。淋巴瘤分级分为低级别或中/高级别。7例接受重复检查的患者，测量结果与其间疾病活性的变化相关。
活性疾病（0.55对0.37毫升/分钟/毫升）和中/高级别淋巴瘤（0.56对0.46毫升/分钟/毫升）的灌注中位数较高。灌注低于0.2毫升/分钟/毫升提示疾病无活性（p<0.03），而>0.5毫升/分钟/毫升提示中/高级别淋巴瘤（p=0.11）。患者组间通透性中位数差异不大。仅疾病无活性时灌注下降。
仅淋巴结的CT灌注测量有评估淋巴瘤分级、活性及治疗反应的潜力。
