类别流畅性在瑞士阿尔茨海默病患者中也主要受到影响。
Category fluency is also predominantly affected in Swiss Alzheimer's disease patients.
作者信息
Monsch A U, Seifritz E, Taylor K I, Ermini-Fünfschilling D, Stähelin H B, Spiegel R
机构信息
Memory Clinic, Geriatric University Clinic, Basel, Switzerland.
出版信息
Acta Neurol Scand. 1997 Feb;95(2):81-4. doi: 10.1111/j.1600-0404.1997.tb00073.x.
OBJECTIVES
To establish the comparative efficacy to differentiate between Swiss patients with dementia of the Alzheimer type (DAT) and elderly normal control subjects (NC) on two different verbal fluency tasks: category fluency and letter fluency.
MATERIAL AND METHODS
Fifty Swiss German DAT patients in the early stages of the disease and 50 matched normal control subjects were compared on letter and category fluency tasks.
RESULTS
DAT patients exhibited an overproportional impairment on category fluency as compared with letter fluency. Receiver operating characteristic curves (ROC) showed that category fluency correctly classified a significantly higher number of DAT patients and NC subjects (84%) than letter fluency (70%).
CONCLUSION
As similar findings have been described for English-speaking DAT patients, we conclude that deficiencies in category fluency are a general phenomenon, reflecting impaired structures of semantic knowledge occurring early in the course of Alzheimer's disease.
目的
通过两项不同的语言流畅性任务（类别流畅性和字母流畅性），确定区分瑞士阿尔茨海默型痴呆（DAT）患者与老年正常对照受试者（NC）的比较疗效。
材料与方法
对50名处于疾病早期的瑞士德语区DAT患者和50名匹配的正常对照受试者进行字母和类别流畅性任务比较。
结果
与字母流畅性相比，DAT患者在类别流畅性上表现出过度比例的损伤。受试者工作特征曲线（ROC）显示，类别流畅性正确分类的DAT患者和NC受试者数量（84%）明显高于字母流畅性（70%）。
结论
由于在说英语的DAT患者中也有类似的发现，我们得出结论，类别流畅性缺陷是一种普遍现象，反映了阿尔茨海默病病程早期语义知识结构受损。
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