喉巨细胞瘤：病例报告及文献复习
Giant cell tumor of the larynx: case report and review of the literature.
作者信息
Werner J A, Harms D, Beigel A
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Germany.
出版信息
Head Neck. 1997 Mar;19(2):153-7. doi: 10.1002/(sici)1097-0347(199703)19:2<153::aid-hed12>3.0.co;2-e.
BACKGROUND
Primary manifestation of a giant cell tumor (GCT) in the larynx is exceedingly rare. Until now, only 17 cases have been reported in the literature. Characterization of a GCT can be difficult partly because of similarities with the giant cell subtype of malignant fibrous histiocytoma (MFH).
METHODS
The case of a 35-year-old man with a laryngeal GCT is presented. The patient underwent laryngectomy and has been free of recurrence since then (90 months). The literature is reviewed, and previously reported cases are presented in a table and compared with the presented case. The difficulties in the differential diagnosis are discussed.
CONCLUSIONS
When a laryngeal GCT is diagnosed, further differential diagnostic considerations should follow. One of these considerations is the MFH, which displays considerably more cellular atypia than GCT. Because most cases of giant cell MFH are high-grade sarcomas, the distinction between GCT and MFH is necessary.
背景
喉巨细胞瘤（GCT）的主要表现极为罕见。截至目前，文献中仅报道了17例。GCT的特征描述可能存在困难，部分原因是其与恶性纤维组织细胞瘤（MFH）的巨细胞亚型相似。
方法
本文介绍了一名35岁男性喉GCT患者的病例。该患者接受了喉切除术，自术后（90个月）以来未复发。回顾了相关文献，并以表格形式呈现了先前报道的病例，并与本文病例进行了比较。讨论了鉴别诊断中的困难。
结论
诊断喉GCT时，应进行进一步的鉴别诊断考量。其中一个考量因素是MFH，它比GCT表现出更多的细胞异型性。由于大多数巨细胞MFH病例为高级别肉瘤，因此区分GCT和MFH很有必要。
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