Lanier L L, Corliss B, Phillips J H
DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, Palo Alto, CA 94304, USA.
Immunol Rev. 1997 Feb;155:145-54. doi: 10.1111/j.1600-065x.1997.tb00947.x.
NK cells express receptors for polymorphic MHC class I molecules that inhibit killing of potential target cells bearing appropriate class I allotypes. Here we review the membrane receptors on human NK cells that are known to initiate cell-mediated cytotoxicity and demonstrate regulation of these responses by the killer cell inhibitory (KIR) receptors.
自然杀伤（NK）细胞表达多态性MHC I类分子的受体，这些受体可抑制对携带适当I类同种异型的潜在靶细胞的杀伤作用。在此，我们综述了已知可引发细胞介导的细胞毒性的人类NK细胞膜受体，并展示了杀伤细胞抑制（KIR）受体对这些反应的调节作用。
