Bødker A, Balslev E, Iversen H G, Meyhoff H H, Andersson K E
Dept. of Urology, Hvidovre Hospital, University of Copenhagen, Denmark.
Scand J Urol Nephrol. 1997 Feb;31(1):15-8. doi: 10.3109/00365599709070295.
In the lower urinary tract of the male rabbit, estrogen receptors (ERs) are restricted to the urethra and the prostatic stroma. At present, the function of ERs in these tissues is not known. Epithelial growth factor (EGF) stimulates proliferation of epidermal and epithelial tissues, and several animal studies have indicated that EGF is regulated by estrogen. On this background, we have studied the effect of castration on the expression of ERs and EGF receptors in the rabbit prostatic urethra and prostate. Twelve male rabbits were studied fourteen days after castration, and eight normal rabbits were included as controls. In the control group, ERs were found in the urothelial lining and lamina propria of the prostatic urethra, and in the prostatic stroma. EGF receptors were demonstrated in the epithelial lining of the prostatic urethra and the glandular epithelium of the prostate. Following castration, the expression of ERs, assessed as the increase in the number of positively stained specimens, increased significantly in the lamina propria of the prostatic urethra and the prostatic stroma. EGF receptor expression increased significantly in the epithelial lining of the prostatic urethra. In the prostate, the increase was not significant. The results give no support to the view that ERs play role in the regulation of EGF receptors in the rabbit prostatic urethra nor the prostate.
在雄性兔的下尿路中，雌激素受体（ERs）局限于尿道和前列腺基质。目前，这些组织中ERs的功能尚不清楚。表皮生长因子（EGF）刺激表皮和上皮组织的增殖，多项动物研究表明EGF受雌激素调节。在此背景下，我们研究了去势对兔前列腺尿道和前列腺中ERs及EGF受体表达的影响。对12只雄性兔在去势14天后进行研究，并纳入8只正常兔作为对照。在对照组中，在前列腺尿道的尿路上皮和固有层以及前列腺基质中发现了ERs。在前列腺尿道的上皮和前列腺的腺上皮中证实有EGF受体。去势后，以阳性染色标本数量的增加来评估，ERs的表达在前列腺尿道固有层和前列腺基质中显著增加。EGF受体表达在前列腺尿道上皮中显著增加。在前列腺中，增加不显著。这些结果不支持ERs在兔前列腺尿道或前列腺中对EGF受体的调节起作用这一观点。
