Achiron R, Ben Arie A, Gabbay U, Mashiach S, Rotstein Z, Lipitz S
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Israel.
Ultrasound Obstet Gynecol. 1997 Jan;9(1):39-41. doi: 10.1046/j.1469-0705.1997.09010039.x.
Our objective was to establish nomograms for fetal tongue measurements from 14 weeks until mid-gestation by using transvaginal and transabdominal high-resolution ultrasound techniques. A prospective, cross-sectional study was performed on 120 normal singleton pregnancies between 14 and 26 weeks of gestation. Tongue circumference was measured by transvaginal ultrasonography between 14 and 17 weeks, and by abdominal ultrasound between 18 and 26 weeks of gestation. Fetal tongue circumference, as a function of gestational age, was expressed by the regression equation: tongue circumference (mm) = -23.9 + 3.75 x gestational age (weeks). The correlation, r2 = 0.95, was found to be highly statistically significant (p < 0.0001). The normal mean of tongue circumference per week and the 95% prediction limits were defined. During the study period we evaluated two cases with tongue circumference outside these 95% confidence limits: one had microglossia, the other macroglossia, and both were found to be associated with abnormal fetal karyotype. The presented normative data may be helpful in the prenatal diagnosis of suspected congenital syndromes that include, among their manifestations, tongue growth disturbances.
我们的目标是通过经阴道和经腹高分辨率超声技术建立从孕14周直至孕中期的胎儿舌测量列线图。对120例孕14至26周的正常单胎妊娠进行了一项前瞻性横断面研究。在孕14至17周通过经阴道超声测量舌周长，在孕18至26周通过腹部超声测量舌周长。胎儿舌周长作为孕周的函数，由回归方程表示：舌周长（mm）=-23.9 + 3.75×孕周（周）。发现相关性r2 = 0.95，具有高度统计学显著性（p < 0.0001）。定义了每周舌周长的正常均值和95%预测范围。在研究期间，我们评估了两例舌周长超出这些95%置信区间的病例：一例有小舌畸形，另一例有巨舌畸形，且两者均被发现与胎儿核型异常有关。所呈现的规范数据可能有助于对包括舌生长障碍表现在内的疑似先天性综合征进行产前诊断。
