Achiron R, Gottlieb Z, Yaron Y, Gabbay M, Gabbay U, Lipitz S, Mashiach S
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Israel.
Prenat Diagn. 1995 Feb;15(2):155-60. doi: 10.1002/pd.1970150208.
Our objective was to establish nomograms for fetal eye measurements from 12 weeks' gestation by using transvaginal and transabdominal high-resolution ultrasound techniques. A prospective cross-sectional study was performed on 450 normal singleton pregnancies between 12 and 37 weeks' gestation. Vitreous and lens circumferences were measured by transvaginal ultrasonography until 17 weeks, and by abdominal ultrasound between 18 and 37 weeks' gestation. Regression analyses were used to create nomograms, and several transformations were done to obtain linearity. Eye measurements of 12 fetuses at risk for ocular disturbances were plotted on the constructed nomograms. Linear relationships were fitted between vitreous (r2 = 0.79) and lens (r2 = 0.88) circumferences and gestational age. In addition, there was a significant correlation between these measurements and the biparietal diameter. Data of the fetuses at risk showed that disturbances in ocular growth were associated mainly with abnormal cerebral development. These normative data may be helpful in the prenatal diagnosis of suspected congenital syndromes that include, among their manifestations, ocular growth disturbances such as microphthalmos and anophthalmos.
我们的目标是通过经阴道和经腹高分辨率超声技术建立妊娠12周起的胎儿眼部测量列线图。对450例妊娠12至37周的正常单胎妊娠进行了一项前瞻性横断面研究。妊娠17周前经阴道超声测量玻璃体和晶状体周长，妊娠18至37周期间经腹部超声测量。采用回归分析创建列线图，并进行了几次变换以获得线性关系。将12例有眼部疾病风险胎儿的眼部测量值绘制在所构建的列线图上。玻璃体（r2 = 0.79）和晶状体（r2 = 0.88）周长与胎龄之间拟合了线性关系。此外，这些测量值与双顶径之间存在显著相关性。有风险胎儿的数据表明，眼部生长障碍主要与脑发育异常有关。这些规范数据可能有助于产前诊断疑似先天性综合征，这些综合征的表现包括眼部生长障碍，如小眼症和无眼症。
