Richmond R L, Kehoe L, de Almeida Neto A C
School of Community Medicine, University of New South Wales, Australia.
Addiction. 1997 Jan;92(1):27-31.
Hospital-based outpatients participating in a cognitive-behavioural group programme (2 hours/week over 5 weeks) were studied to evaluate the effectiveness of a 24-hour transdermal nicotine patch in assisting smokers to stop smoking when used as an adjunct to a cognitive-behavioural group programme, and to assess weight gain following cessation, using a randomized, double-blind, placebo-controlled trial with 12 months' follow-up. The main outcome measure was a comparison between point prevalence abstinence, continuous abstinence and 12-months sustained, biochemically validated abstinence. The validated abstinence rates at 12 months for point prevalence, sustained and continuous abstinence for subjects in the active and placebo groups were all statistically significant: 28 vs. 12%; 24 vs. 11%; and 19 vs. 9%, respectively. Moderately dependent smokers using the nicotine patch were more successful than highly dependent smokers at 3 and 6 months (p < 0.05). Weight gain was greater among sustained abstainers at 12 months compared to continuing smokers (p < 0.001). When the active nicotine patch was used in combination with cognitive-behavioural therapy in an outpatient hospital clinic, 12-months sustained abstinence rates were more than double those of a placebo patch.
以医院为基础的门诊患者参加了一个认知行为团体项目（每周2小时，共5周），该项研究采用随机、双盲、安慰剂对照试验并进行12个月的随访，以评估24小时透皮尼古丁贴片作为认知行为团体项目辅助手段帮助吸烟者戒烟的有效性，以及评估戒烟后的体重增加情况。主要结局指标是时点患病率戒烟、持续戒烟和12个月持续且经生化验证的戒烟之间的比较。活性组和安慰剂组受试者在12个月时经验证的时点患病率戒烟率、持续戒烟率和连续戒烟率均具有统计学意义：分别为28%对12%、24%对11%、19%对9%。在3个月和6个月时，使用尼古丁贴片的中度依赖吸烟者比高度依赖吸烟者更成功（p<0.05）。与持续吸烟者相比，持续戒烟者在12个月时体重增加更多（p<0.001）。在门诊医院诊所将活性尼古丁贴片与认知行为疗法联合使用时，12个月持续戒烟率是安慰剂贴片的两倍多。
