Yao L, Gentili A, Seeger L L
Department of Radiological Sciences, University of California, Los Angeles, 90095, USA.
Acad Radiol. 1997 Feb;4(2):127-31. doi: 10.1016/s1076-6332(97)80011-6.
The authors compared saline and dilute gadopentetate dimeglumine as injectants for magnetic resonance (MR) arthrography.
Sixty-three lesions were created on the joint surfaces of six pig patellas. MR arthrography (1.5 T) was performed with the specimens in saline and then in 2 mmol gadopentetate dimeglumine by using fat-saturated two-dimensional (2D) and three-dimensional (3D) sequences. Two musculoskeletal radiologists independently interpreted the images.
At 2D MR arthrography, reader 1 performed equally well with saline and gadolinium solutes, whereas reader 2 had better sensitivity with the saline solute (P < .05); interobserver agreement was equivalent for saline and gadolinium solutes. With 3D MR arthrography, reader 2 performed equally well with saline and gadolinium solutes, whereas reader 1 had better sensitivity (P < .0001) but poorer specificity (P < .001) with the gadolinium solute; interobserver agreement was significantly better for saline than for gadopentetate dimeglumine (P < .05).
In this initial evaluation, there was no clear advantage to using gadolinium-enhanced MR arthrography over saline MR arthrography for detecting lesions in porcine hyaline cartilage.
作者比较了生理盐水和稀释的钆喷酸葡胺作为磁共振（MR）关节造影剂的效果。
在六只猪髌骨的关节表面制造63处损伤。使用脂肪抑制二维（2D）和三维（3D）序列，先将标本置于生理盐水中，然后置于2 mmol钆喷酸葡胺中进行MR关节造影（1.5 T）。两名肌肉骨骼放射科医生独立解读图像。
在2D MR关节造影中，观察者1对生理盐水和钆溶质的表现相同，而观察者2对生理盐水溶质的敏感性更高（P <.05）；生理盐水和钆溶质的观察者间一致性相当。在3D MR关节造影中，观察者2对生理盐水和钆溶质的表现相同，而观察者1对钆溶质的敏感性更高（P <.0001）但特异性较差（P <.001）；生理盐水的观察者间一致性明显优于钆喷酸葡胺（P <.05）。
在这项初步评估中，对于检测猪透明软骨中的损伤，使用钆增强MR关节造影并不比生理盐水MR关节造影有明显优势。
