Thornes R D
Vet Rec. 1977 Jul 9;101(2):27-30. doi: 10.1136/vr.101.2.27.
Dysfunction of the cellular immune mechanism was found in 23 patients with persistent symptoms of brucellosis of more than one year's duration when skin tested for delayed hypersensitivity to dinitrochlorobenzene (DNCB). Eighteen patients had low normal or depressed E rosetting capacity of their lymphocytes. Anti-anergic treatment with levamisole 150 mg daily for one month and for two consecutive days each week for six months produced an exacerbation of symptoms after one to four weeks followed by complete relief from symptoms in 15 patients and partial relief in four. Vitamin A was used to potentiate the effect of levamisole in seven patients.
对23例病程超过一年、有布鲁氏菌病持续症状的患者进行二硝基氯苯（DNCB）迟发型超敏反应皮肤试验时，发现其细胞免疫机制功能异常。18例患者淋巴细胞的E玫瑰花结形成能力处于低正常水平或降低。用左旋咪唑每日150毫克治疗一个月，然后每周连续两天，共六个月，进行抗无反应性治疗，1至4周后症状加剧，随后15例患者症状完全缓解，4例部分缓解。7例患者使用维生素A增强左旋咪唑的效果。
