Raptopoulou-Gigi M, Kountouras J, Goulis G
J Immunopharmacol. 1980;2(1):85-97. doi: 10.3109/08923978009026390.
Ten patients with chronic brucellosis were treated with levamisole, 150mg daily for 3 consecutive days every week for 6 months. Patients were followed up for another 6 months after the end of treatment. By the end of the treatment period, patients improved clinically, their E rosettes showed a significant increase and specific leukocyte inhibition migration factor (LIF) was produced. By the end of the follow up period, all patients except one became symptom free, antiglobulin titers were very low or negative, E rosettes showed a further increase ranging to normal levels and specific LIF activity was not detected to most of the patients. Our results suggest that levamisole might prove to be beneficial in the treatment of chronic brucellosis.
10例慢性布鲁氏菌病患者接受了左旋咪唑治疗，每周每日150mg，连续3天，共6个月。治疗结束后对患者进行了另外6个月的随访。到治疗期结束时，患者临床症状改善，E玫瑰花结显著增加，并产生了特异性白细胞抑制迁移因子（LIF）。到随访期结束时，除1例患者外，所有患者均无症状，抗球蛋白滴度非常低或为阴性，E玫瑰花结进一步增加至正常水平，且大多数患者未检测到特异性LIF活性。我们的结果表明，左旋咪唑可能对慢性布鲁氏菌病的治疗有益。
