Page V J, Chhipa J H
Department of Anaesthetics, Hammersmith Hospital, London, UK.
Acta Anaesthesiol Scand. 1997 Feb;41(2):256-9. doi: 10.1111/j.1399-6576.1997.tb04676.x.
Metoclopramide has been shown to reduce the dose of thiopentone required for induction of anaesthesia. When propofol is used, there have been conflicting results with one small study showing a reduction in the anaesthetic dose and one study failing to demonstrate any effect.
Two groups of 30 patients were studied. The patients were randomised to receive either saline 0.03 ml/mg or metoclopramide 0.15 mg/kg 5 min before a manual injection of propofol at a set rate.
This study shows a reduction in the dose of propofol required for the induction of general anaesthesia following an intravenous dose of metoclopramide. The induction dose of propofol was reduced by 24%.
The mechanism of reduction of propofol dose by metoclopramide is unknown; it may involve GABA or result from a more complex interaction involving dopamine blockade by metoclopramide.
已表明甲氧氯普胺可降低诱导麻醉所需的硫喷妥钠剂量。当使用丙泊酚时，结果存在矛盾，一项小型研究显示麻醉剂量降低，而另一项研究未能证明有任何效果。
对两组各30例患者进行研究。在以设定速率手动注射丙泊酚前5分钟，将患者随机分组，分别接受0.03 ml/mg生理盐水或0.15 mg/kg甲氧氯普胺。
本研究表明静脉注射甲氧氯普胺后，诱导全身麻醉所需的丙泊酚剂量降低。丙泊酚的诱导剂量降低了24%。
甲氧氯普胺降低丙泊酚剂量的机制尚不清楚；可能涉及γ-氨基丁酸，或源于甲氧氯普胺阻断多巴胺的更复杂相互作用。
