Chirico G, Gasparoni A, Ciardelli L, De Amici M, Colombo A, Rondini G
Division of Neonatology and Neonatal Intensive Care, Policlinico San Matteo, IRCCS, Pavia, Italy.
Allergy. 1997 Jan;52(1):82-8. doi: 10.1111/j.1398-9995.1997.tb02549.x.
We evaluated the immunogenicity and antigenicity of a formula based on partially hydrolyzed cow's milk whey protein in infants at risk of atopy and in controls. Total IgE and specific IgE, IgG, and IgG4 subclass antibodies against egg albumin and cow's milk alpha-lactalbumin, casein, and beta-lactoglobulin were measured by radioimmunoassay of cord blood and of peripheral blood at 5 days and 6 months of life in five groups of infants: 16 breast-fed infants at risk of atopy (group 1), 21 partially hydrolyzed whey formula-fed infants at risk of atopy (group 2), 14 formula-fed infants at risk of atopy (group 3), 10 breast-fed control infants (group 4), and 13 formula-fed control infants (group 5). Total IgE concentration was significantly lower in group 2 at 6 months than in groups 3 and 5 infants and similar to that observed in groups 1 and 4 infants. The concentration of specific antiegg and anti-cow's milk protein IgG and of specific anti-cow's milk alpha-lactalbumin and beta-lactoglobulin IgG4 subclass antibodies was significantly reduced in group 2 as compared to group 3 infants and similar to that found in breast-fed infants. In conclusion, the partially hydrolyzed formula was less immunogenic and antigenic than a traditional formula and was as immunogenic and antigenic as breast milk.
我们评估了一种基于部分水解牛奶乳清蛋白的配方奶粉在有特应性风险的婴儿和对照组婴儿中的免疫原性和抗原性。通过放射免疫分析法检测了五组婴儿脐带血以及出生5天和6个月时外周血中针对卵清蛋白、牛奶α-乳白蛋白、酪蛋白和β-乳球蛋白的总IgE、特异性IgE、IgG和IgG4亚类抗体：16名有特应性风险的母乳喂养婴儿（第1组）、21名有特应性风险的部分水解乳清配方奶粉喂养婴儿（第2组）、14名有特应性风险的配方奶粉喂养婴儿（第3组）、10名母乳喂养的对照婴儿（第4组）和13名配方奶粉喂养的对照婴儿（第5组）。第2组婴儿在6个月时的总IgE浓度显著低于第3组和第5组婴儿，与第1组和第4组婴儿中观察到的浓度相似。与第3组婴儿相比，第2组中特异性抗卵和抗牛奶蛋白IgG以及特异性抗牛奶α-乳白蛋白和β-乳球蛋白IgG4亚类抗体的浓度显著降低，与母乳喂养婴儿中的浓度相似。总之，部分水解配方奶粉的免疫原性和抗原性低于传统配方奶粉，且与母乳的免疫原性和抗原性相当。
