Rao M R, Kanji V K, Setty V V, Wang C, Salahudeen A K, Das S K, Cohly H H
Department of Medicine, University of Mississippi Medical Center, Jackson 39216, USA.
Indian J Physiol Pharmacol. 1996 Apr;40(2):183-5.
Cyclosporin A (CsA) is a cyclic undecapeptide that has been used extensively as an immunosuppressive drug in transplantation medicine and is known to interact with L-arginine dependent pathways. We studied the in vitro and in vivo effects of CsA on nitric oxide synthase (NOS) activity in the rat kidney. CsA in concentrations of 44-2200 nM in vitro, and 12.5 or 25 mg/kg body weight per 4 weeks treated rat kidneys in vivo, significantly stimulated NOS activity. CsA may alter the Ca2+/Cam-dependent NOS activity by interacting with rat kidney Ca2+/calmodulin dependent events.
环孢素A（CsA）是一种环十一肽，在移植医学中作为免疫抑制药物被广泛使用，已知它可与L-精氨酸依赖性途径相互作用。我们研究了CsA对大鼠肾脏中一氧化氮合酶（NOS）活性的体外和体内作用。体外浓度为44 - 2200 nM的CsA，以及体内每4周以12.5或25 mg/kg体重处理大鼠肾脏，均显著刺激了NOS活性。CsA可能通过与大鼠肾脏中Ca2+/钙调蛋白依赖性事件相互作用来改变Ca2+/钙调蛋白依赖性NOS活性。
