Ries M, Klinge J, Rauch R
Klinik mit Poliklinik für Kinder und Jugendliche, Universität Erlangen-Nürnberg, Germany.
Thromb Res. 1997 Feb 15;85(4):341-4. doi: 10.1016/s0049-3848(97)00019-4.
The physiology of the hemostatic system in infancy and childhood is different from that in adulthood. Despite differences in several components of the coagulation and fibrinolytic systems, there is no evidence that children are at greater risk for hemorrhagic or thrombotic problems compared with adults (1,2). Advances in understanding of the biochemistry of the hemostatic mechanism have led to the development of sensitive immunochemical methods for measuring peptides or enzyme-inhibitor complexes that are liberated with the activation of the coagulation and fibrinolytic systems in vivo (3). Activation markers of coagulation and fibrinolysis have been measured in newborns, infants and children with a variety of underlying disorders (4-16). However, reference ranges for children of different age groups have hitherto not been established. The aim of the present study was to document thrombin-antithrombin III-complex (TAT), prothrombin fragment 1 + 2 (F1 + 2), plasmin-alpha 2-antiplasmin-complex (PAP) and D-dimer in healthy children and to determine whether age-related differences can be demonstrated.
婴儿期和儿童期止血系统的生理学与成年期不同。尽管凝血和纤溶系统的几个组成部分存在差异，但没有证据表明与成年人相比，儿童发生出血或血栓形成问题的风险更高(1,2)。对止血机制生物化学认识的进展导致了灵敏的免疫化学方法的发展，用于测量体内凝血和纤溶系统激活时释放的肽或酶抑制剂复合物(3)。已经在患有各种潜在疾病的新生儿、婴儿和儿童中测量了凝血和纤溶的激活标志物(4 - 16)。然而，不同年龄组儿童的参考范围迄今尚未确定。本研究的目的是记录健康儿童的凝血酶 - 抗凝血酶III复合物(TAT)、凝血酶原片段1 + 2(F1 + 2)、纤溶酶 - α2 - 抗纤溶酶复合物(PAP)和D - 二聚体，并确定是否能证明与年龄相关的差异。
