Kodama H, Fukuda J, Karube H, Matsui T, Shimizu Y, Tanaka T
Department of Obstetrics and Gynecology, Akita University School of Medicine, Japan.
Fertil Steril. 1996 Sep;66(3):417-24. doi: 10.1016/s0015-0282(16)58512-4.
To elucidate characteristic changes of plasma hemostatic markers in ovarian hyperstimulation syndrome (OHSS) cycles.
Prospective study.
The IVF-ET program of the Department of Obstetrics and Gynecology, The University of Akita, School of Medicine.
Forty cycles of 40 IVF patients, including 12 cycles in which a severe form of OHSS occurred.
Blood samples were taken during IVF treatment to determine the levels of blood markers that reflect activation of the coagulation and fibrinolytic systems.
Thrombin-antithrombin III complexes, plasmin-alpha 2 antiplasmin complexes, and other hemostatic markers related to the coagulation and fibrinolytic system activation.
In the OHSS cycles, the levels of thrombin-antithrombin III and plasmin-alpha 2 antiplasmin complexes in the plasma began to rise within a few days after hCG administration and demonstrated significantly higher levels during the midluteal phase. In OHSS cycles with pregnancy, elevation of these markers continued for > or = 3 weeks after the onset of disease. There were some characteristic changes in OHSS cycles in other hemostatic markers, such as a decrease in the levels of antithrombin III and prekallikrein and shortened activated partial thromboplastin time.
These data demonstrate the status of the coagulation and fibrinolytic systems in OHSS cycles and provide insight into the mechanism of activation in the hemostatic system.
阐明卵巢过度刺激综合征（OHSS）周期中血浆止血标志物的特征性变化。
前瞻性研究。
秋田大学医学院妇产科的体外受精-胚胎移植项目。
40例体外受精患者的40个周期，其中12个周期发生了严重形式的OHSS。
在体外受精治疗期间采集血样，以测定反映凝血和纤溶系统激活的血液标志物水平。
凝血酶-抗凝血酶III复合物、纤溶酶-α2抗纤溶酶复合物以及与凝血和纤溶系统激活相关的其他止血标志物。
在OHSS周期中，血浆中凝血酶-抗凝血酶III和纤溶酶-α2抗纤溶酶复合物的水平在注射人绒毛膜促性腺激素（hCG）后几天内开始升高，并在黄体中期显示出明显更高的水平。在妊娠的OHSS周期中，这些标志物的升高在疾病发作后持续≥3周。OHSS周期中的其他止血标志物存在一些特征性变化，如抗凝血酶III和前激肽释放酶水平降低以及活化部分凝血活酶时间缩短。
这些数据证明了OHSS周期中凝血和纤溶系统的状态，并为止血系统的激活机制提供了见解。
