Simeonov S
Vet Med Nauki. 1977;14(3):105-10.
Induced was chronic copper poisoning in sheep treated orally with copper sulphate. Investigated was the dynamics of some of the clinical picture aspects, the paraclinical behaviour, and the toxicogenesis of poisoning. The disease manifested a three-phase course. The hemolytic crisis at various liver levels of copper within therange of from 315 up to 840.5 mg/kg was due to the challenging role of additional factors, such as pregnancy, lambing, lactation and individual sensitivity. During pregnancy copper was found to pass though the placenta, accumulating in the liver of the fetus. Copper deposition in the liver lobes varied. The quantitative determination of liver copper requires the investigation of pool samples.
通过给绵羊口服硫酸铜诱导其发生慢性铜中毒。研究了中毒的一些临床症状方面、副临床行为及毒理发生过程的动态变化。该病呈现出三个阶段的病程。在肝脏铜含量处于315至840.5毫克/千克范围内时，溶血危象是由诸如妊娠、产羔、哺乳及个体敏感性等其他因素的激发作用所致。在妊娠期间，发现铜可穿过胎盘，在胎儿肝脏中蓄积。肝脏各叶中的铜沉积情况各不相同。肝脏铜的定量测定需要对混合样本进行研究。
