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含有紫杉醇和/或紫杉烷酯作为活性物质的玛丽吉醇浓缩物。

Marigenol-concentrates comprising Taxol and/or Taxan esters as active substances.

作者信息

Eugster C, Rivara G, Forni G, Vai S

机构信息

Marigen S.A., Riehen.

出版信息

Panminerva Med. 1996 Dec;38(4):234-42.

PMID:9063032
Abstract

Marigen is a Swiss Research Company based in Riehen (Canton of Basle). It has developed and tested a Solubilization System for its phytosteryl ester compounds having antitumor and antiviral/virucidal activity. By formulating spontaneously dispersible concentrates, which comprise such compounds, it is now possible to produce thermodynamically stable, aqueous ultramicroemulsions which achieve outstanding bioavailability and bio-reactivity for the active principles comprised in these Marigenol-Concen-trates. As a consequence, unwanted side-effects are drastically reduced in therapeutical use or even completely absent, and the economy of the system permits a remarkable optimization of the dose-efficacy relationship and hence also of drug safety.

摘要

马里根是一家位于里亨(巴塞尔州)的瑞士研究公司。它已为其具有抗肿瘤和抗病毒/杀病毒活性的植物甾醇酯化合物开发并测试了一种增溶系统。通过配制包含此类化合物的自发分散浓缩物,现在有可能生产出热力学稳定的水性超微乳液,这些乳液对于这些马里根醇浓缩物中所含的活性成分具有出色的生物利用度和生物反应性。因此,在治疗用途中,不良副作用会大幅减少甚至完全不存在,并且该系统的经济性允许显著优化剂量-疗效关系,从而也优化了药物安全性。

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