角鲨胺诱导的细胞死亡的细胞毒性及电子显微镜观察
Cytotoxicity and electron microscopy of cell death induced by goniothalamin.
作者信息
Ali A M, Mackeen M M, Hamid M, Aun Q B, Zauyah Y, Azimahtol H L, Kawazu K
机构信息
Department of Biotechnology, Faculty of Food Science and Biotechnology, Universiti Pertanian Malaysia, Selangor, Malaysia.
出版信息
Planta Med. 1997 Feb;63(1):81-3. doi: 10.1055/s-2006-957611.
The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultrastructural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells.
结果发现，角鲨胺对癌细胞系（HGC - 27、MCF - 7、PANC - 1、HeLa）和非癌细胞系（3T3）均具有很强的细胞毒性，尤其是对处于分裂期的细胞。药物暴露研究表明，角鲨胺的细胞毒性作用具有时间和剂量依赖性。在超微结构水平上，角鲨胺诱导的细胞毒性显示出对MCF - 7细胞的坏死性细胞死亡模式。
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