羊膜移植治疗伴有溃疡形成的持续性上皮缺损。
Amniotic membrane transplantation for persistent epithelial defects with ulceration.
作者信息
Lee S H, Tseng S C
机构信息
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Florida.
出版信息
Am J Ophthalmol. 1997 Mar;123(3):303-12. doi: 10.1016/s0002-9394(14)70125-4.
PURPOSE
To determine whether preserved human amniotic membrane can be used as an alternative substrate for treating persistent corneal epithelial defects with sterile ulceration.
METHODS
Amniotic membrane transplantation was performed in 11 eyes of 11 consecutive patients with corneal ulcers of different causes that had persisted for a mean +/- SD of 17.5 +/- 13.9 weeks.
RESULTS
Ten patients healed in 3.9 +/- 2.3 weeks (P < .01) without recurrence for 9.0 +/- 5.9 months. One patient failed to heal because of preexisting corneal perforation pursuant to severe rheumatoid arthritis.
CONCLUSION
Amniotic membrane transplantation may be considered an alternative method for treating persistent epithelial defects and sterile ulceration that are refractory to conventional treatment and before considering treatment by conjunctival flaps or tarsorrhaphy.
目的
确定保存的人羊膜是否可作为治疗伴有无菌性溃疡的持续性角膜上皮缺损的替代基质。
方法
对11例不同病因的角膜溃疡连续患者的11只眼进行羊膜移植，这些溃疡持续时间平均为17.5±13.9周（均值±标准差）。
结果
10例患者在3.9±2.3周内愈合（P<.01），9.0±5.9个月内无复发。1例患者因严重类风湿关节炎导致先前角膜穿孔而未愈合。
结论
对于传统治疗无效的持续性上皮缺损和无菌性溃疡，在考虑结膜瓣或睑裂缝合术治疗之前，羊膜移植可被视为一种替代方法。
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