Radcliffe M, Meyer M, Roditi D, Malan A
Department of Paediatrics, Groote Schuur Hospital.
S Afr Med J. 1997 Jan;87(1):62-5.
To determine the efficacy of single-dose benzathine penicillin G in infants at high risk of congenital syphilis.
Randomised study comparing benzathine penicillin with no therapy.
Peninsula Maternal and Neonatal Service, Cape Town.
Asymptomatic infants born to mothers with untreated syphilis whose VDRL titre was 32 or more.
The number of cases of congenital syphilis was determined by results of IgM Western blots and follow-up VDRL titres.
Of 8 patients followed up in the non-treatment group, 4 had congenital syphilis while 0/11 had the disease (P = 0.035) in the group receiving benzathine penicillin. Although the exact failure rate is unknown, benzathine penicillin is effective in preventing symptomatic congenital syphilis when administered to high-risk newborns.
确定单剂量苄星青霉素G对先天性梅毒高危婴儿的疗效。
将苄星青霉素与不治疗进行比较的随机研究。
开普敦半岛母婴服务中心。
母亲患有未经治疗的梅毒、VDRL滴度为32或更高的无症状婴儿。
先天性梅毒病例数通过IgM免疫印迹结果和后续VDRL滴度确定。
在未治疗组随访的8例患者中，4例患有先天性梅毒，而在接受苄星青霉素治疗的组中，11例中有0例患该病（P = 0.035）。虽然确切的失败率尚不清楚，但苄星青霉素用于高危新生儿时可有效预防有症状的先天性梅毒。
