La Rosa F, Patavino V M, Epifani A C, Petrinelli A M, Minelli L, Mastrandrea V
Department of Hygiene, Perugia University, Italy.
Tumori. 1996 Sep-Oct;82(5):441-3. doi: 10.1177/030089169608200505.
We analyzed the 10-year survival of 1,512 women with breast cancer in relation to age at diagnosis. The incident cases were from an ad hoc investigation in Umbria, a region of central Italy, for the period 1978-1982. The follow-up was carried out by an automatic link with the RENCAM (Nominative register of causes of death) and verified at the Register's Offices of the various towns of the region. Observed survival at 1 year was 0.89, at 3 years 0.75, at 5 years 0.64 and at 10 years 0.47. Median survival was 9.0 years. Relative survival at 1, 3, 5, 10 years was respectively 0.91, 0.79, 0.71 and 0.59. Women < 35 years of age had a better prognosis both at 5 (0.83) and 10 years (0.69) from diagnosis. Thereafter, survival decreased with increasing age. The exception to this trend was women in the 45-49 and 60-64 year age ranges, for which survival was greater than the previous age range classes by 6% and 13%, respectively, at 5 years from diagnosis and 6% and 14% at 10 years. Comparison of data from Umbria and Italian and European Registries shows that the prognosis for Umbrian women with breast cancer is quite good.
我们分析了1512例乳腺癌女性患者的10年生存率与诊断时年龄的关系。这些发病病例来自意大利中部翁布里亚地区1978 - 1982年期间的一项专项调查。随访通过与RENCAM（死亡原因命名登记册）自动链接进行，并在该地区各个城镇的登记办公室进行核实。观察到的1年生存率为0.89，3年生存率为0.75，5年生存率为0.64，10年生存率为0.47。中位生存期为9.0年。1年、3年、5年、10年的相对生存率分别为0.91、0.79、0.71和0.59。年龄小于35岁的女性在诊断后5年（0.83）和10年（0.69）的预后较好。此后，生存率随年龄增长而下降。这一趋势的例外是年龄在45 - 49岁和60 - 64岁之间的女性，在诊断后5年，她们的生存率分别比前一年龄组高6%和13%，在10年时分别高6%和14%。翁布里亚地区与意大利及欧洲登记处数据的比较表明，翁布里亚地区乳腺癌女性患者的预后相当好。
