Leach R M, Sokol C, McMurtry J P
Department of Poultry Science, Pennsylvania State University, University Park 16802-3501, USA.
Domest Anim Endocrinol. 1997 Mar;14(2):129-32. doi: 10.1016/s0739-7240(96)00120-8.
Recent evidence clearly indicates that basic fibroblast growth factor (bFGF) signal transduction is essential for normal skeletal development. Here, we report that bFGF and its receptor are specifically localized in the terminal hypertrophic chondrocytes of the porcine epiphyseal growth plate, the tissue responsible for longitudinal bone growth. Similar observations were obtained with the chondrocytes immediately adjacent to resorbing blood vessels in the secondary center of ossification of the epiphysis. These results are consistent with a recent proposal that bFGF functions in coupling osteogenesis with chondrogenesis by attracting the vascular invasion of cartilage from adjacent trabecular bone.
近期证据清楚地表明，碱性成纤维细胞生长因子（bFGF）信号转导对于正常骨骼发育至关重要。在此，我们报告bFGF及其受体特异性定位于猪骨骺生长板的终末肥大软骨细胞中，该组织负责骨骼的纵向生长。在骨骺骨化次级中心紧邻正在吸收的血管的软骨细胞中也得到了类似的观察结果。这些结果与最近的一项提议一致，即bFGF通过吸引来自相邻小梁骨的软骨血管侵入，在成骨与软骨形成的耦合中发挥作用。
