Baron J, Klein K O, Yanovski J A, Novosad J A, Bacher J D, Bolander M E, Cutler G B
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892.
Endocrinology. 1994 Dec;135(6):2790-3. doi: 10.1210/endo.135.6.7988472.
In mammals, longitudinal bone growth results from the precise coupling of chondrogenesis and osteogenesis within the epiphyseal growth plate, a process termed endochondral ossification. The mechanisms coupling chondrogenesis and osteogenesis are unknown. Previous studies have shown that both basic fibroblast growth factor (bFGF) and acidic FGF are expressed by growth plate chondrocytes. Here we show that bFGF, infused directly into the rabbit proximal tibial growth plate, accelerates vascular invasion and ossification of growth plate cartilage. Our results suggest the possibility that bFGF (or a related member of the FGF family) couples osteogenesis to chondrogenesis by attracting vascular and bone cell invasion from the adjacent metaphyseal bone.
在哺乳动物中，纵向骨生长源于骨骺生长板内软骨生成和成骨的精确耦合，这一过程称为软骨内成骨。软骨生成和成骨耦合的机制尚不清楚。先前的研究表明，碱性成纤维细胞生长因子（bFGF）和酸性FGF均由生长板软骨细胞表达。在此我们表明，直接注入兔胫骨近端生长板的bFGF可加速生长板软骨的血管侵入和骨化。我们的结果提示，bFGF（或FGF家族的相关成员）可能通过吸引来自相邻干骺端骨的血管和骨细胞侵入，将成骨与软骨生成耦合起来。
