Claudepierre P, Allanore Y, Larget-Piet B, Chevalier X
Rheumatology Department, Henri Mondor Teaching Hospital, Creteil, France.
Rev Rhum Engl Ed. 1996 Jan;63(1):56-8.
The prognosis of large granular lymphocyte proliferation with rheumatoid arthritis (pseudo-Felty's syndrome) remains uncertain. We report a case with a 15-year follow-up. To date, the patient has not developed lymphadenopathy, splenomegaly, abnormalities in erythrocyte or platelet counts, neutropenia or severe or unexplained infections. This favorable course is not ascribable to an unusual lymphocyte phenotype (CD3+, CD8+, CD57+). A beneficial effect of methotrexate therapy is possible.
类风湿关节炎合并大颗粒淋巴细胞增殖(假性费尔蒂综合征)的预后仍不确定。我们报告一例随访15年的病例。迄今为止,该患者未出现淋巴结病、脾肿大、红细胞或血小板计数异常、中性粒细胞减少或严重或不明原因的感染。这种良好的病程并非归因于异常的淋巴细胞表型(CD3 +、CD8 +、CD57 +)。甲氨蝶呤治疗可能具有有益效果。