Kretschmar C, Kaumeier S, Haase W
III. Psychiatrische Klinik, Klinik für Suchtkrankheiten, Schwerin.
Fortschr Med. 1996 Nov 20;114(32):439-43.
In a randomized double-blind study involving 303 patients with alcoholic polyneuropathy the efficacy and tolerability of the combinations thiamine/pyridoxine, benfotiamine/pyridoxine, and the nucleotides of cytidine and uridine administered orally for 21 days were compared. Pain and paraesthesia, measured on a visual 10-cm-long analogue scale, as also pallaesthesia and the strength of the dorsiflexion and plantar flexors of the foot, clearly improved in all treatment groups. Clinically relevant differences in efficacy were not observed. All the drugs tested were well tolerated.
在一项涉及303例酒精性多发性神经病患者的随机双盲研究中，比较了口服硫胺素/吡哆醇、苯磷硫胺/吡哆醇以及胞苷和尿苷核苷酸组合21天的疗效和耐受性。所有治疗组中，通过10厘米长的视觉模拟量表测量的疼痛和感觉异常，以及振动觉和足部背屈与跖屈的力量均明显改善。未观察到疗效上的临床相关差异。所有测试药物耐受性良好。
