Hartmann A, Heuser I
Max-Planck-Institut für Psychiatrie, Klinisches Institut, München.
Fortschr Neurol Psychiatr. 1996 Nov;64(11):444-51. doi: 10.1055/s-2007-996590.
Steroids which are synthesised de novo in the CNS are termed neurosteroids. In contrast to classical non-genomic steroid effects, neurosteroids interact with GABAa and NMDA receptors localized on the cell membrane. This mode of action implies an influence of neurosteroids on a variety of central nervous processes. More specifically, this compound class could act as an endogenous anxiolytic agent through modulation of the GABAa receptor complex, thereby presenting potential advantages over existing classes of anxiolytics, e.g. benzodiazepines, with regard to tolerance, dependence and abuse liability. The present paper reviews the current state of research in this field.
在中枢神经系统中重新合成的类固醇被称为神经甾体。与经典的非基因组类固醇效应不同，神经甾体与位于细胞膜上的GABAa和NMDA受体相互作用。这种作用方式意味着神经甾体对多种中枢神经过程有影响。更具体地说，这类化合物可通过调节GABAa受体复合物充当内源性抗焦虑剂，因此在耐受性、依赖性和滥用倾向方面，相对于现有的抗焦虑药物（如苯二氮䓬类药物）具有潜在优势。本文综述了该领域的当前研究状况。
