Calixto González E, Brailowsky S
Departamento de Neurociencias, Instituto de Fisiología Celular y Fisiología Humana, Facultad de Medicina, UNAM, México.
Gac Med Mex. 1998 Jan-Feb;134(1):69-84.
Steroids which are produced by the brain are called neurosteroids, and they are able to modulate neurotransmissions: GABAergic; glutamatergic; glycinergic, and cholinergic (nicotine receptor). These effects are of short latency and duration, and do not implicate the cellular genome. The interaction of these neurosteroids with membrane receptors contribute to the regulation of neuronal excitability, and their study has allowed a better understanding of cognitive, hormonal, and epileptic phenomena as well as the development of new drugs with anxiolytic, antidepressive, anesthetic and anti-epileptic effects.
由大脑产生的类固醇被称为神经甾体，它们能够调节神经传递：γ-氨基丁酸能、谷氨酸能、甘氨酸能和胆碱能（尼古丁受体）。这些作用的潜伏期和持续时间较短，且不涉及细胞基因组。这些神经甾体与膜受体的相互作用有助于调节神经元兴奋性，对它们的研究有助于更好地理解认知、激素和癫痫现象，以及开发具有抗焦虑、抗抑郁、麻醉和抗癫痫作用的新药。
