鉴定一种由CD40L快速诱导产生的共刺激分子，即CD44H。
Identification of a costimulatory molecule rapidly induced by CD40L as CD44H.
作者信息
Guo Y, Wu Y, Shinde S, Sy M S, Aruffo A, Liu Y
机构信息
Michael Heidelberger Division of Immunology, Department of Pathology, New York University Medical Center, New York 10016, USA.
出版信息
J Exp Med. 1996 Sep 1;184(3):955-61. doi: 10.1084/jem.184.3.955.
Abstract
The interaction between CD40 ligand and CD40 is critical for activation of T and B cells in vivo. We have recently demonstrated that this interaction rapidly induces a novel costimulatory activity distinct from B7 and independent of CD28. To study the molecular basis of the costimulatory activity, we have produced a novel monoclonal antibody, TM-1, that binds an 85-kilodalton costimulatory molecule rapidly induced by CD40L. Expression cloning reveals that TM-1 binds CD44H. CD44H expressed on Chinese hamster ovary cells has potent costimulatory activity for clonal expansion of T cells isolated from both wild-type mice and these with a targeted mutation of CD28. Thus, CD44H costimulates T cell proliferation by a CD28-independent mechanism. These results revealed that CD44H is a costimulatory molecule rapidly induced by CD40L.
摘要
CD40配体与CD40之间的相互作用对于体内T细胞和B细胞的激活至关重要。我们最近证明，这种相互作用能迅速诱导一种不同于B7且不依赖于CD28的新型共刺激活性。为了研究这种共刺激活性的分子基础，我们制备了一种新型单克隆抗体TM-1，它能结合由CD40L迅速诱导产生的一种85千道尔顿的共刺激分子。表达克隆显示TM-1结合CD44H。在中国仓鼠卵巢细胞上表达的CD44H对从野生型小鼠和CD28靶向突变小鼠中分离出的T细胞克隆扩增具有强大的共刺激活性。因此，CD44H通过一种不依赖于CD28的机制共刺激T细胞增殖。这些结果表明，CD44H是一种由CD40L迅速诱导产生的共刺激分子。
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本文引用的文献
1
A cysteine residue located in the transmembrane domain of CD44 is important in binding of CD44 to hyaluronic acid.位于CD44跨膜结构域的一个半胱氨酸残基在CD44与透明质酸的结合中起重要作用。
J Exp Med. 1996 May 1;183(5):1987-94. doi: 10.1084/jem.183.5.1987.
2
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Curr Biol. 1995 Nov 1;5(11):1303-11. doi: 10.1016/s0960-9822(95)00257-0.
3
CD40 ligand-transduced co-stimulation of T cells in the development of helper function.CD40配体转导的共刺激在辅助功能发育中的T细胞作用
Nature. 1995 Dec 7;378(6557):620-3. doi: 10.1038/378620a0.
4
Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand.缺乏CD40配体的小鼠中抗原特异性T细胞启动受损。
Nature. 1995 Dec 7;378(6557):617-20. doi: 10.1038/378617a0.
5
CD44 and its interaction with extracellular matrix.CD44及其与细胞外基质的相互作用。
Adv Immunol. 1993;54:271-335. doi: 10.1016/s0065-2776(08)60537-4.
6
The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44.不变链的硫酸软骨素形式可通过与CD44相互作用增强对T细胞反应的刺激。
Cell. 1993 Jul 30;74(2):257-68. doi: 10.1016/0092-8674(93)90417-o.
7
A major costimulatory molecule on antigen-presenting cells, CTLA4 ligand A, is distinct from B7.抗原呈递细胞上的一种主要共刺激分子，CTLA4配体A，与B7不同。
J Exp Med. 1993 Nov 1;178(5):1789-93. doi: 10.1084/jem.178.5.1789.
8
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Nature. 1994 Feb 3;367(6462):425-8. doi: 10.1038/367425a0.
9
CD40 ligand mutations in x-linked immunodeficiency with hyper-IgM.X连锁高IgM免疫缺陷中的CD40配体突变
Nature. 1993 Feb 11;361(6412):541-3. doi: 10.1038/361541a0.
10
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Immunity. 1994 Aug;1(5):423-31. doi: 10.1016/1074-7613(94)90073-6.
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