Mustafa A, Nyberg F, Bogdanovic N, Islam A, Suliman I, Lindgren U, Roos P, Adem A
Department of Pharmaceutical Biosciences, Uppsala University, Sweden.
Neurosci Lett. 1995 Nov 24;200(3):179-82. doi: 10.1016/0304-3940(95)12106-e.
The effects of long-term ovariectomy on the levels of brain and liver lactogenic binding sites as well as plasma and liver prolactin (PRL) have been investigated in sham-operated and ovariectomized rats receiving either 17 beta estradiol (OVX-E), progesterone (OVX-P), or vehicle (OVX-V). The levels of lactogenic binding sites in the parietal and piriform cortices, amygdala, thalamus, hypothalamus, as well as in the liver were significantly decreased after long-term ovariectomy. Moreover, the levels of plasma and liver PRL were also significantly decreased. Exogenous estradiol and progesterone replacement restored the levels of lactogenic binding sites in the parietal cortex and hypothalamus as well as in the liver. However, plasma and liver PRL levels were significantly increased by estradiol but only restored by progesterone. These results suggest that ovarian steroids influence the levels of lactogenic binding sites and prolactin.
在接受17β-雌二醇（OVX-E）、孕酮（OVX-P）或赋形剂（OVX-V）的假手术和去卵巢大鼠中，研究了长期去卵巢对脑和肝催乳素结合位点水平以及血浆和肝催乳素（PRL）的影响。长期去卵巢后，顶叶和梨状皮质、杏仁核、丘脑、下丘脑以及肝脏中的催乳素结合位点水平显著降低。此外，血浆和肝PRL水平也显著降低。外源性雌二醇和孕酮替代恢复了顶叶皮质、下丘脑以及肝脏中催乳素结合位点的水平。然而，雌二醇使血浆和肝PRL水平显著升高，而孕酮仅使其恢复。这些结果表明，卵巢类固醇会影响催乳素结合位点和催乳素的水平。
