Mustafa A, Bogdanovic N, Nyberg F, Suliman I, Islam A, Roos P, Winblad B, Adem A
Department of Pharmaceutical Biosciences, Uppsala University, Sweden.
Neurosci Lett. 1995 Jul 21;194(3):193-6. doi: 10.1016/0304-3940(95)11759-p.
The effects of long-term ovariectomy and replacement with ovarian steroids on the levels of brain and liver somatogenic binding sites as well as plasma and liver growth hormone (GH) were studied in sham-operated (Sham) and ovariectomized female rats receiving either, 17 beta-estradiol (OVX-E), progesterone (OVX-P), or vehicle (OVX). Long-term ovariectomy decreased the levels of somatogenic binding sites in the choroid plexus and liver as well as GH in plasma and liver. The levels of these sites in the choroid plexus were partially restored only by estradiol replacement. Moreover, exogenous estradiol but not progesterone restored the levels of plasma and liver GH as well as liver somatogenic binding sites. Our results suggest that estrogens regulate the levels of somatogenic binding sites in the liver and choroid plexus.
在接受17β-雌二醇（OVX-E）、孕酮（OVX-P）或赋形剂（OVX）的假手术（Sham）和去卵巢雌性大鼠中，研究了长期卵巢切除并用卵巢类固醇替代对脑和肝脏生长激素结合位点水平以及血浆和肝脏生长激素（GH）的影响。长期卵巢切除降低了脉络丛和肝脏中生长激素结合位点的水平以及血浆和肝脏中GH的水平。仅通过雌二醇替代，脉络丛中这些位点的水平才部分恢复。此外，外源性雌二醇而非孕酮恢复了血浆和肝脏GH以及肝脏生长激素结合位点的水平。我们的结果表明，雌激素调节肝脏和脉络丛中生长激素结合位点的水平。
