Häusler U H, Lutzenberger W, Birbaumer N
Institut für Medizinische Psychologie und Verhaltensneurobiologie Universität Tübingen, Germany.
Neurosci Lett. 1995 Nov 24;200(3):183-6. doi: 10.1016/0304-3940(95)12107-f.
Recording of slow brain potentials (SPs) and transcranial magnetic stimulation (TCMS) of the human motor cortex were combined to probe the relationship between SP level and excitability of cortical neurons. In experiment 1, TCMS was applied during and shortly after the warning interval in a forewarned reaction time task. Electromyographic (EMG) responses to TCMS increased only slightly during the warning interval and were significantly elevated 150 ms after the imperative stimulus. In experiment 2, TCMS was applied during biofeedback-induced cortical positivity and negativity. In this non-motor task a dependence of TCMS response on SP amplitude was not significant. Results indicate higher local excitability of motor cortex during cortical negativity when a preparatory motor task is required. TCMS may better be suited to probe processes involved in motor tasks rather than non-motor and cognitive conditions.
将人类运动皮层的慢脑电位（SPs）记录与经颅磁刺激（TCMS）相结合，以探究SP水平与皮层神经元兴奋性之间的关系。在实验1中，在有预警的反应时间任务的预警间隔期间及之后不久施加TCMS。在预警间隔期间，对TCMS的肌电图（EMG）反应仅略有增加，而在指令刺激后150毫秒显著升高。在实验2中，在生物反馈诱导的皮层正电位和负电位期间施加TCMS。在这个非运动任务中，TCMS反应对SP幅度的依赖性不显著。结果表明，当需要准备性运动任务时，在皮层负电位期间运动皮层的局部兴奋性较高。TCMS可能更适合于探究运动任务中涉及的过程，而不是非运动和认知状态。
