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碳丝与胎儿组织共同植入挫伤大鼠脊髓后的电生理改善

Electrophysiological improvement after co-implantation of carbon filaments and fetal tissue in the contused rat spinal cord.

作者信息

Liu L S, Khan T, Sayers S T, Dauzvardis M F, Trausch C L

机构信息

Rehabilitation Research and Development Center, Hines Veterans Administration Hospital, IL 60141, USA.

出版信息

Neurosci Lett. 1995 Nov 24;200(3):199-202. doi: 10.1016/0304-3940(95)12131-m.

DOI:10.1016/0304-3940(95)12131-m
PMID:9064611
Abstract

The electrophysiological integrity of the adult rat spinal cord was assessed at the lumbar, lower cervical and cortical levels after the animals sustained a severe contusion injury at the mid-thoracic level (T8) and received either carbon filament cultured with fetal spinal cord tissue implants, fetal tissue implants, or carbon filament implants alone. Somatosensory evoked potentials (SSEPs) and motor evoked potentials (MEPs) were recorded from all animal groups at the end of the 8-week survival period. The results of this study demonstrate that the spinal cord injured animals that received carbon filament cultured with fetal spinal cord tissue implants had the highest degree of electrophysiological recovery, indicating that this combination plays an important role in promoting recovery after injury.

摘要

在成年大鼠胸段中部(T8)遭受严重挫伤性损伤后,对其腰椎、下颈段和皮质水平的脊髓电生理完整性进行评估,这些大鼠分别接受了与胎儿脊髓组织植入物共培养的碳丝植入、胎儿组织植入或仅碳丝植入。在8周存活期结束时,记录所有动物组的体感诱发电位(SSEPs)和运动诱发电位(MEPs)。本研究结果表明,接受与胎儿脊髓组织植入物共培养的碳丝植入的脊髓损伤动物具有最高程度的电生理恢复,这表明这种组合在促进损伤后恢复中起重要作用。

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