Burger M M
Friedrich-Miescher-Institut, Basel.
Schweiz Med Wochenschr. 1997 Feb 1;127(5):142-7.
Biological alterations of tumor cells which lead to metastasizing properties can now be identified in some cases in specific molecules (adhesion molecules, proteases, cytoskeleton, angiogenesis factors). To explain organ-specific metastasis, organ-specific mechanisms of adhesion to endothelial and parenchymal cells have been in the forefront for two decades. Based primarily, but not exclusively, on animal models, we must include more and more paracrine growth factors produced by the target organ, including the lung.
肿瘤细胞导致转移特性的生物学改变现在在某些情况下可以在特定分子（黏附分子、蛋白酶、细胞骨架、血管生成因子）中被识别。为了解释器官特异性转移，器官特异性黏附于内皮细胞和实质细胞的机制已经在前沿领域存在了二十年。主要但不限于基于动物模型，我们必须纳入越来越多由靶器官（包括肺）产生的旁分泌生长因子。
