Bonczkowitz M, Weyers W
Zentrum für Dermatologie und Andrologie, Justus-Liebig-Universität Giessen.
Verh Dtsch Ges Pathol. 1996;80:235-40.
Lymphocytic infiltration and lupus erythematosus have many features in common. The main distinguishing factor is the lack of epidermal involvement in lymphocytic infiltration, as compared to the frequent presence of epidermal changes in discoid lupus erythematosus. Other factors claimed to differentiate between both conditions are lack of antinuclear antibodies, negative immunofluorescence findings, and the more frequent presence of plasmacytoid monocytes in lymphocytic infiltration. To evaluate the significance of those findings, we studied cases of lymphocytic infiltration and lupus erythematosus with and without epidermal changes, using the same set of clinical, histopathological, and immunological criteria. No differences were found between lymphocytic infiltrates in cases with and without epidermal involvement. Based on those findings, lymphocytic infiltration seems to be a morphological variant of lupus erythematosus, rather than a distinct entity.
淋巴细胞浸润与红斑狼疮有许多共同特征。主要的区别因素是淋巴细胞浸润不存在表皮受累情况，而盘状红斑狼疮则经常出现表皮变化。其他据称可区分这两种情况的因素包括缺乏抗核抗体、免疫荧光检查结果为阴性，以及淋巴细胞浸润中浆细胞样单核细胞更为常见。为评估这些发现的意义，我们使用同一组临床、组织病理学和免疫学标准，对有或无表皮变化的淋巴细胞浸润和红斑狼疮病例进行了研究。在有或无表皮受累的病例中，淋巴细胞浸润之间未发现差异。基于这些发现，淋巴细胞浸润似乎是红斑狼疮的一种形态学变异，而非一种独立的疾病实体。
