Molina J A, de Bustos F, Jiménez-Jiménez F J, Benito-León J, Gasalla T, Ortí-Pareja M, Vela L, Bermejo F, Martín M A, Campos Y, Arenas J
Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain.
Neurology. 1997 Mar;48(3):636-8. doi: 10.1212/wnl.48.3.636.
We studied respiratory chain enzyme activities in lymphocyte mitochondria from 33 patients with Alzheimer's disease (AD) and from 30 age- and sex-matched healthy controls. The respiratory chain enzyme activities did not differ significantly between patients and controls. No patient showed any value for respiratory chain enzyme levels below normal range. Values for activities of complexes in the AD group did not correlate with age at onset or duration of the disease. Our finding of normal mitochondrial function in lymphocyte mitochondria suggests that this tissue cannot be used to demonstrate the involvement of oxidative phosphorylation in AD and, thus, to develop a diagnostic test for AD.
我们研究了33例阿尔茨海默病（AD）患者及30名年龄和性别匹配的健康对照者淋巴细胞线粒体中的呼吸链酶活性。患者和对照者之间的呼吸链酶活性没有显著差异。没有患者的呼吸链酶水平值低于正常范围。AD组中各复合体的活性值与发病年龄或疾病持续时间无关。我们在淋巴细胞线粒体中发现线粒体功能正常，这表明该组织不能用于证明氧化磷酸化在AD中的作用，因此也不能用于开发AD的诊断测试。
