Ko T, Muramatsu T, Shirai T
Department of Dermatology, Nara Medical University, Kashihara, Japan.
J Dermatol. 1997 Feb;24(2):104-9. doi: 10.1111/j.1346-8138.1997.tb02752.x.
We report a case of lymphoepithelioma-like carcinoma of the skin on the right cheek of a 67-year-old man. Histologically, the entire dermis was occupied by multiple lobules of atypical epithelial tumor cell nests surrounded by inflammatory cells. Immunohistochemical examination showed that the epithelial tumor cells were positive for cytokeratin and epithelial membrane antigen. The inflammatory cells were positive for leukocyte common antigen and T-cell marker. Among the tumor nests, small ductal structures were positive for carcinoembryonic antigen. Ultrastructurally, these epithelial tumor cells had well-developed desmosomes and were joined to each other; no tonofilaments were observed in the cytoplasm. These findings strongly suggest that these tumor cells tended to differentiate to the adnexa of the skin.
我们报告一例发生于一名67岁男性右侧脸颊的皮肤淋巴上皮瘤样癌。组织学上，整个真皮层被多个非典型上皮肿瘤细胞巢小叶占据，周围有炎症细胞。免疫组化检查显示上皮肿瘤细胞细胞角蛋白和上皮膜抗原呈阳性。炎症细胞白细胞共同抗原和T细胞标志物呈阳性。在肿瘤巢中，小导管结构癌胚抗原呈阳性。超微结构上，这些上皮肿瘤细胞有发达的桥粒且相互连接；细胞质中未观察到张力丝。这些发现强烈提示这些肿瘤细胞倾向于向皮肤附属器分化。
