Kapadia G J, Balasubramanian V, Tokuda H, Konoshima T, Takasaki M, Koyama J, Tagahaya K, Nishino H
Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Howard University, Washington, D.C. 20059, USA.
Cancer Lett. 1997 Feb 26;113(1-2):47-53. doi: 10.1016/s0304-3835(96)04582-x.
In continuation of our studies of natural and synthetic products as cancer chemopreventive agents, we have examined a number of naphthoquinone derivatives including monomeric, dimeric and tetrameric naphthaquinones occurring in the Diospyros and other selected plant genera. Several synthetic naphthoquinones were also evaluated. Initially these compounds were tested for in vitro anti-tumor promoting effect on Epstein-Barr virus early antigen activation produced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and thereafter in in vivo on two-stage mouse skin carcinogenesis. Our studies show some of these compounds have potent anti-tumor promoting activity.
作为我们对天然和合成产品作为癌症化学预防剂研究的延续，我们研究了多种萘醌衍生物，包括柿属植物及其他选定植物属中存在的单体、二聚体和四聚体萘醌。还评估了几种合成萘醌。最初，这些化合物在体外针对肿瘤促进剂12-O-十四烷酰佛波醇-13-乙酸酯（TPA）诱导的爱泼斯坦-巴尔病毒早期抗原激活进行了抗肿瘤促进作用测试，随后在体内对两阶段小鼠皮肤致癌作用进行了测试。我们的研究表明，其中一些化合物具有强大的抗肿瘤促进活性。
