Rauf Abdur, Akram Zuneera, Hafeez Nabia, Khalil Anees Ahmed, Khalid Ahood, Abid Zoya, Hemeg Hassan A, Aljohani Abdullah S M, Al Abdulmonem Waleed, Quradha Mohammed Mansour
Department of Chemistry University of Swabi Anbar Khyber Pakhtunkhwa Pakistan.
Department of Pharmacology, Faculty of Pharmaceutical Sciences Baqai Medical University Karachi Pakistan.
Food Sci Nutr. 2024 Aug 13;12(10):7033-7047. doi: 10.1002/fsn3.4375. eCollection 2024 Oct.
The genus has gained significant attention in the scientific community owing to its diverse bioactivities ascribed to specific bioactive constituents present in different species of this plant. Phytochemicals like flavonoids, terpenoids, and xanthones have been reported to be present in other species responsible for their pharmacological properties. These compounds are well known for their diverse potent therapeutic potentials, such as antimicrobial, antioxidant, anti-inflammatory, and anticancer properties. This review enlightens the details of the Genus Diospyros, ranging from an overview of its species to an in-depth analysis of phytochemistry, ethnopharmacology, and their potential as anticancer agents. Different species, including , , , , and , presented with an enormous range of anticancer activities against human cancer cell cultures. Moreover, this review highlights the results of various in vitro (antiproliferative, cytotoxic effects against), in vivo (inhibition of tumor, apoptosis), and (GLU234, GLU278, and LYS158 protein residues) studies, elucidating its preclinical anticancer potential. The anticancer potential displays inhibition of cellular proliferation, induction of apoptosis, and mitigation of angiogenesis. Furthermore, this review may elaborate the use of traditional knowledge, modern research, and potential therapeutic applications in the field of anticancer ethnopharmacology. As the modern-day research approaches novel alternatives to combat diseases like cancer, the Genus Diospyros may emerge as a promising avenue with the potential to yield innovative and effective therapeutic agents.
由于该属植物的不同物种中存在特定的生物活性成分，具有多种生物活性，因此在科学界受到了广泛关注。据报道，其他该属植物物种中存在黄酮类、萜类和呫吨酮类等植物化学物质，这些物质赋予了它们药理特性。这些化合物以其多样的强大治疗潜力而闻名，如抗菌、抗氧化、抗炎和抗癌特性。本综述详细介绍了柿属植物，从其物种概述到植物化学、民族药理学及其作为抗癌剂潜力的深入分析。包括[具体物种1]、[具体物种2]、[具体物种3]、[具体物种4]和[具体物种5]在内的不同物种，对人类癌细胞培养物呈现出广泛的抗癌活性。此外，本综述突出了各种体外（抗增殖、细胞毒性作用）、体内（肿瘤抑制、凋亡）和[此处原文可能有误，不太明确具体内容]（GLU234、GLU278和LYS158蛋白残基）研究的结果，阐明了其临床前抗癌潜力。抗癌潜力表现为抑制细胞增殖、诱导凋亡和减轻血管生成。此外，本综述可能会阐述传统知识、现代研究以及抗癌民族药理学领域潜在治疗应用的情况。随着现代研究探索对抗癌症等疾病的新方法，柿属植物可能会成为一个有前景的途径，有潜力产生创新且有效的治疗药物。
