Ohashi Y
Department of Ophthalmology, Ehime University School of Medicine, Japan.
Ophthalmologica. 1997;211 Suppl 1:29-32. doi: 10.1159/000310883.
Since the introduction of acyclovir in the last decade, the visual prognosis of herpetic keratitis has improved dramatically. Benefits with this superb agent include rapid resolution of epithelial keratitis, reduction of disturbances in ocular surface epithelia, and a decreased incidence of necrotizing keratitis or subsequent corneal melting. On the other hand, persistent superficial punctate keratopathy associated with topical usage, emergence of an acyclovir-resistant strain of herpes simplex virus, and a gradual increase in progressive corneal endotheliitis comprise the problems to be resolved.
自上世纪九十年代阿昔洛韦问世以来，疱疹性角膜炎的视力预后有了显著改善。这种卓越药物的益处包括上皮性角膜炎迅速消退、眼表上皮紊乱减少以及坏死性角膜炎或随后角膜溶解的发生率降低。另一方面，与局部用药相关的持续性浅层点状角膜病变、单纯疱疹病毒阿昔洛韦耐药株的出现以及进行性角膜内皮炎的逐渐增加，都是有待解决的问题。
